Treatment-resistant Depression is different. Marplan® (isocarboxazid) is different, too.
Antidepressant drugs are thought to elevate a person's mood by raising the levels of chemical messengers in the brain called neurotransmitters. The chemical names of the neurotransmitters are norepinephrine, serotonin and dopamine. Scientists believe that some antidepressant medications may work by raising the amount of serotonin in the brain. Others may work by raising norepinephrine levels; and still others by raisng levels of dopamine.
Globally, about 50% of patients respond to treatment with these antidepressants, but a great many people, like yourself may respond partially or not at all.
Marplan is different from more widely used antidepressant medications because it is an MAO-Inhibitor (MAO-I).
Only MAO-Inhibiting drugs like Marplan raise the level of all three neurotransmitters - and that may account for its well known efficacy in treatment-resistant depression.
Marplan Indications (Uses)
Marplan is approved for use in the treatment of depression. Treatment with Marplan requires special attention from both the doctor and the patient because it has the potential to cause serious side effects if it is used incorrectly. That's why Marplan is not the first antidepressant a doctor uses when treating newly diagnosed depressed patients.
The efficacy of Marplan in the treatment of depression was established in 6-week controlled trials of depressed outpatients. These patients had symptoms that corresponded to the DSM-IV category of major depressive disorder; however, they often also had signs and symptoms of anxiety (anxious mood, panic, and/or phobic symptoms).
A major depressive episode (DSM-IV) implies a prominent and relatively persistent (nearly every day for at least 2 weeks) depressed or dysphoric
mood that usually interferes with daily functioning, and includes at least five of the following nine symptoms: depressed mood, loss of interest in usual
activities, significant change in weight and/or appetite, insomnia or hypersomnia, psychomotor agitation or retardation, increased fatigue, feelings of guilt or worthlessness, slowed thinking or impaired concentration, and a suicide
attempt or suicidal ideation.
Please see Full Prescribing Information including BOXED WARNINGS regarding increased risk of suicidality in children and adolescents. MAO-Inhibitors are contraindicated with certain drugs. Potential hypertensive crises may occur with foods that contain tyramine. As with all antidepressants, patients should be observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of treatment.
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